Effect of rapamycin alone and in combination with sorafenib

Effect of rapamycin alone and in combination with sorafenib in an orthotopic model of human hepatocellular carcinoma.

 

OBJECTIVE
Novel therapeutic strategies are needed to prevent the tumor recurrence or metastasis after liver transplantation for hepatocellular carcinoma (HCC). This study was to investigate the effect of rapamycin, alone and in combination with sorafenib, on HCC in vivo.
METHODS
Xenograft of a highly metastatic human HCC tumor (LCI-D20) was used to evaluate primary tumor growth and lung metastasis after treatment with rapamycin alone or in combination with sorafenib.
Tumor cell proliferation was determined by Ki-67 immunostaining. To detect tumor cell apoptosis, the terminal deoxynucleotidyl-transferase-mediated dUTP nick-end labeling assay was used. Tumor angiogenesis was investigated by using a monoclonal anti-CD31 antibody.
A vascular endothelial growth factor ELISA kit was used to measure vascular endothelial growth factor protein levels in the mice serum.
RESULTS
Rapamycin, alone and in combination with sorafenib, strongly inhibited primary tumor growth and lung metastases in LCI-D20 model.
Furthermore, the combination therapy significantly enhanced the effect of antitumor on primary tumor growth compared with single treatment with either rapamycin (P < 0.001) or sorafenib (P < 0.001).
Rapamycin alone inhibited HCC cell proliferation, induced apoptosis, and decreased tumor angiogenesis. Nevertheless, the combination therapy showed a significant inhibition of tumor cell proliferation (P < 0.05).
Additionally, the combination therapy also further enhanced suppression of tumor cell angiogenesis compared with rapamycin treatment (P < 0.01). However, the induction of apoptosis in combination therapy group was not significantly higher than in the rapamycin-treated group (P>> 0.05).
CONCLUSIONS
The combination therapy of rapamycin and sorafenib could be a new and promising therapeutic approach to the treatment of HCC and prevention of HCC recurrence after liver transplantation.
novecsin
novecsin

Human WW and C2 domain containing 1 (WWC1) Control/blocking peptide

AB-23076-P 100ug
EUR 196.8

Mouse zinc finger, BED domain containing 3 (ZBED3) Control/blocking peptide

AB-23250-P 100ug
EUR 196.8

Mouse NLR family, pyrin domain containing 4F (NLRP4F) Control/blocking peptide

AB-23251-P 100ug
EUR 196.8

Human Pleckstrin homology domain containing, family A member 7 (PLEKHA7) Control/blocking peptide

AB-23061-P 100ug
EUR 196.8

SYN3 Blocking Peptide

33R-3176 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of SYN3 antibody, catalog no. 70R-10563

SYN2 Blocking Peptide

DF7862-BP 1mg
EUR 234

Dog LMBR1 domain containing 1 ELISA kit

E08L1189    -192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Canine LMBR1 domain containing 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog LMBR1 domain containing 1 ELISA kit

E08L1189    -48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Canine LMBR1 domain containing 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog LMBR1 domain containing 1 ELISA kit

E08L1189    -96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Canine LMBR1 domain containing 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig LMBR1 domain containing 1 ELISA kit

E07L1189    -192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Porcine LMBR1 domain containing 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig LMBR1 domain containing 1 ELISA kit

E07L1189    -48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Porcine LMBR1 domain containing 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig LMBR1 domain containing 1 ELISA kit

E07L1189    -96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Porcine LMBR1 domain containing 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat LMBR1 domain containing 1 ELISA kit

E06L1189    -192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Goat LMBR1 domain containing 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat LMBR1 domain containing 1 ELISA kit

E06L1189    -48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Goat LMBR1 domain containing 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat LMBR1 domain containing 1 ELISA kit

E06L1189    -96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Goat LMBR1 domain containing 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse LMBR1 domain containing 1 ELISA kit

E03L1189-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Mouse LMBR1 domain containing 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse LMBR1 domain containing 1 ELISA kit

E03L1189-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Mouse LMBR1 domain containing 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse LMBR1 domain containing 1 ELISA kit

E03L1189-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Mouse LMBR1 domain containing 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey LMBR1 domain containing 1 ELISA kit

E09L1189    -192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Monkey LMBR1 domain containing 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey LMBR1 domain containing 1 ELISA kit

E09L1189    -48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Monkey LMBR1 domain containing 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey LMBR1 domain containing 1 ELISA kit

E09L1189    -96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Monkey LMBR1 domain containing 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Isoprenoid Synthase Domain Containing (ISPD) ELISA Kit

abx391508-96tests 96 tests
EUR 1093.2

Human SH2- containing protein ELISA Kit

ELA-E1205h 96 Tests
EUR 988.8

Guinea pig LMBR1 domain containing 1 ELISA kit

E01L1189-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Guinea pig LMBR1 domain containing 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig LMBR1 domain containing 1 ELISA kit

E01L1189-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Guinea pig LMBR1 domain containing 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig LMBR1 domain containing 1 ELISA kit

E01L1189-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Guinea pig LMBR1 domain containing 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Isoprenoid Synthase Domain Containing (ISPD) ELISA Kit

abx389663-96tests 96 tests
EUR 1093.2

Human Isoprenoid Synthase Domain Containing (ISPD) ELISA Kit

abx385057-96tests 96 tests
EUR 1093.2

Mouse GH3 Domain Containing (GHDC) ELISA Kit

abx389397-96tests 96 tests
EUR 1093.2

Human GH3 Domain Containing (GHDC) ELISA Kit

abx387551-96tests 96 tests
EUR 1093.2

Rat LYR Motif Containing 1 (LYRM1) ELISA Kit

abx391565-96tests 96 tests
EUR 1093.2

Rat Valosin Containing Protein (VCP) ELISA Kit

DLR-VCP-Ra-48T 48T
EUR 658.8
Description: A sandwich quantitative ELISA assay kit for detection of Rat Valosin Containing Protein (VCP) in samples from tissue homogenates or other biological fluids.

Rat Valosin Containing Protein (VCP) ELISA Kit

DLR-VCP-Ra-96T 96T
EUR 861.6
Description: A sandwich quantitative ELISA assay kit for detection of Rat Valosin Containing Protein (VCP) in samples from tissue homogenates or other biological fluids.

Rat Valosin Containing Protein (VCP) ELISA Kit

20-abx156219
  • EUR 8684.40
  • EUR 4626.00
  • EUR 1074.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Rat Valosin Containing Protein (VCP) ELISA Kit

SEC601Ra-10x96wellstestplate 10x96-wells test plate
EUR 6149.04
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Valosin Containing Protein (VCP) in Tissue homogenates and other biological fluids.

Rat Valosin Containing Protein (VCP) ELISA Kit

SEC601Ra-1x48wellstestplate 1x48-wells test plate
EUR 611.57
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Valosin Containing Protein (VCP) in Tissue homogenates and other biological fluids.

Rat Valosin Containing Protein (VCP) ELISA Kit

SEC601Ra-1x96wellstestplate 1x96-wells test plate
EUR 822.24
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Valosin Containing Protein (VCP) in Tissue homogenates and other biological fluids.

Rat Valosin Containing Protein (VCP) ELISA Kit

SEC601Ra-5x96wellstestplate 5x96-wells test plate
EUR 3340.08
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Valosin Containing Protein (VCP) in Tissue homogenates and other biological fluids.

Rat Valosin Containing Protein (VCP) ELISA Kit

4-SEC601Ra
  • EUR 6210.00
  • EUR 3280.80
  • EUR 823.20
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Rat Valosin Containing Protein (VCP) in samples from Tissue homogenates and other biological fluids. with no significant corss-reactivity with analogues from other species.

Rat Valosin Containing Protein (VCP) ELISA Kit

RD-VCP-Ra-48Tests 48 Tests
EUR 668.4

Rat Valosin Containing Protein (VCP) ELISA Kit

RD-VCP-Ra-96Tests 96 Tests
EUR 930

Rat Valosin Containing Protein (VCP) ELISA Kit

RDR-VCP-Ra-48Tests 48 Tests
EUR 699.6

Rat Valosin Containing Protein (VCP) ELISA Kit

RDR-VCP-Ra-96Tests 96 Tests
EUR 973.2

Rat Valosin Containing Protein (VCP) ELISA Kit

RDR-VCP-Ra-48T 48T
EUR 512.09
Description: tissue homogenates and other biological fluids.

Rat Valosin Containing Protein (VCP) ELISA Kit

RDR-VCP-Ra-96T 96T
EUR 731.54
Description: tissue homogenates and other biological fluids.

Rat Valosin Containing Protein (VCP) ELISA Kit

RD-VCP-Ra-48T 48T
EUR 487.7
Description: tissue homogenates and other biological fluids.

Rat Valosin Containing Protein (VCP) ELISA Kit

RD-VCP-Ra-96T 96T
EUR 696.7
Description: tissue homogenates and other biological fluids.

Rat Valosin Containing Protein (VCP) ELISA Kit

DL-VCP-Ra 96T
EUR 475
Description: tissue homogenates or other biological fluids.

Rat Valosin Containing Protein (VCP) ELISA Kit

DLR-VCP-Ra 96T
EUR 499
Description: tissue homogenates or other biological fluids.

Rat DTW Domain Containing 1 (DTWD1) ELISA Kit

abx391251-96tests 96 tests
EUR 1093.2

Human EH Domain Containing 1 (EHD1) ELISA Kit

abx387069-96tests 96 tests
EUR 1093.2

Human EH Domain Containing 2 (EHD2) ELISA Kit

abx387070-96tests 96 tests
EUR 1093.2

Human EH Domain Containing 3 (EHD3) ELISA Kit

abx387071-96tests 96 tests
EUR 1093.2

Human EH Domain Containing 4 (EHD4) ELISA Kit

abx387072-96tests 96 tests
EUR 1093.2

Human LYR Motif Containing 7 (LYRM7) ELISA Kit

abx388358-96tests 96 tests
EUR 1093.2

Mouse HD Domain Containing 2 (HDDC2) ELISA Kit

abx389499-96tests 96 tests
EUR 1093.2

Mouse LYR Motif Containing 1 (LYRM1) ELISA Kit

abx389780-96tests 96 tests
EUR 1093.2

Rat CUE Domain Containing 2 (CUEDC2) ELISA Kit

abx391163-96tests 96 tests
EUR 1093.2

Human LYR Motif Containing 1 (LYRM1) ELISA Kit

abx385109-96tests 96 tests
EUR 1093.2

Cow THAP Domain Containing 4 (THAP4) ELISA Kit

abx520382-96tests 96 tests
EUR 1093.2

Rat THAP Domain Containing 4 (THAP4) ELISA Kit

abx520385-96tests 96 tests
EUR 801.6

Human SMYD3(SET and MYND domain containing 3) ELISA Kit

EH12445 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 18.75pg/ml

Dog Sprouty related EVH1 domain containing 1 ELISA kit

E08S0460-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Canine Sprouty related EVH1 domain containing 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Sprouty related EVH1 domain containing 1 ELISA kit

E08S0460-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Canine Sprouty related EVH1 domain containing 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Sprouty related EVH1 domain containing 1 ELISA kit

E08S0460-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Canine Sprouty related EVH1 domain containing 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Sprouty related EVH1 domain containing 1 ELISA kit

E02S0460-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Rat Sprouty related EVH1 domain containing 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Sprouty related EVH1 domain containing 1 ELISA kit

E02S0460-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Rat Sprouty related EVH1 domain containing 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Sprouty related EVH1 domain containing 1 ELISA kit

E02S0460-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Rat Sprouty related EVH1 domain containing 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Sprouty related EVH1 domain containing 1 ELISA kit

E07S0460-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Porcine Sprouty related EVH1 domain containing 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Sprouty related EVH1 domain containing 1 ELISA kit

E07S0460-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Porcine Sprouty related EVH1 domain containing 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Sprouty related EVH1 domain containing 1 ELISA kit

E07S0460-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Porcine Sprouty related EVH1 domain containing 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Amine Oxidase, Copper Containing 3 ELISA Kit (AOC3)

RK02601 96 Tests
EUR 625.2

Mouse Asparagine Synthetase Domain Containing 1 (ASNSD1) ELISA Kit

abx388619-96tests 96 tests
EUR 1093.2

Human Asparagine Synthetase Domain Containing 1 (ASNSD1) ELISA Kit

abx384603-96tests 96 tests
EUR 1093.2

Human Valosin Containing Protein (VCP) ELISA Kit

DLR-VCP-Hu-48T 48T
EUR 620.4
Description: A sandwich quantitative ELISA assay kit for detection of Human Valosin Containing Protein (VCP) in samples from serum, plasma, tissue homogenates or other biological fluids.

Human Valosin Containing Protein (VCP) ELISA Kit

DLR-VCP-Hu-96T 96T
EUR 807.6
Description: A sandwich quantitative ELISA assay kit for detection of Human Valosin Containing Protein (VCP) in samples from serum, plasma, tissue homogenates or other biological fluids.

Human Valosin Containing Protein (VCP) ELISA Kit

20-abx153462
  • EUR 8853.60
  • EUR 4719.60
  • EUR 1093.20
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Valosin Containing Protein (VCP) ELISA Kit

SEC601Hu-10x96wellstestplate 10x96-wells test plate
EUR 5677.8
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Valosin Containing Protein (VCP) in tissue homogenates, cell lysates and other biological fluids.

Human Valosin Containing Protein (VCP) ELISA Kit

SEC601Hu-1x48wellstestplate 1x48-wells test plate
EUR 572.76
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Valosin Containing Protein (VCP) in tissue homogenates, cell lysates and other biological fluids.

Human Valosin Containing Protein (VCP) ELISA Kit

SEC601Hu-1x96wellstestplate 1x96-wells test plate
EUR 766.8
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Valosin Containing Protein (VCP) in tissue homogenates, cell lysates and other biological fluids.

Human Valosin Containing Protein (VCP) ELISA Kit

SEC601Hu-5x96wellstestplate 5x96-wells test plate
EUR 3090.6
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Valosin Containing Protein (VCP) in tissue homogenates, cell lysates and other biological fluids.

Human Valosin Containing Protein (VCP) ELISA Kit

4-SEC601Hu
  • EUR 5738.40
  • EUR 3031.20
  • EUR 768.00
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Valosin Containing Protein (VCP) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species.

Human Valosin Containing Protein ELISA Kit (VCP)

RK02490 96 Tests
EUR 625.2

Human Valosin Containing Protein (VCP) ELISA Kit

RD-VCP-Hu-48Tests 48 Tests
EUR 625.2

Human Valosin Containing Protein (VCP) ELISA Kit

RD-VCP-Hu-96Tests 96 Tests
EUR 867.6

Human Valosin Containing Protein (VCP) ELISA Kit

RDR-VCP-Hu-48Tests 48 Tests
EUR 652.8

Human Valosin Containing Protein (VCP) ELISA Kit

RDR-VCP-Hu-96Tests 96 Tests
EUR 907.2

Human Valosin Containing Protein (VCP) ELISA Kit

RDR-VCP-Hu-48T 48T
EUR 475.34
Description: serum, plasma, tissue homogenates and other biological fluids.

Autoimmune liver serology: current diagnostic and clinical challenges.

Liver-related autoantibodies are crucial for the correct diagnosis and classification of autoimmune liver diseases (AiLD), namely autoimmune hepatitis types 1 and 2 (AIH-1 and 2), primary biliary cirrhosis (PBC), and the sclerosing cholangitis variants in adults and children.
AIH-1 is specified by anti-nuclear antibody (ANA) and smooth muscle antibody (SMA). AIH-2 is specified by antibody to liver kidney microsomal antigen type-1 (anti-LKM1) and anti-liver cytosol type 1 (anti-LC1). SMA, ANA and anti-LKM antibodies can be present in de-novo AIH following liver transplantation.
PBC is specified by antimitochondrial antibodies (AMA) reacting with enzymes of the 2-oxo-acid dehydrogenase complexes (chiefly pyruvate dehydrogenase complex E2 subunit) and disease-specific ANA mainly reacting with nuclear pore gp210 and nuclear body sp100.
Sclerosing cholangitis presents as at least two variants, first the classical primary sclerosing cholangitis (PSC) mostly affecting adult men wherein the only (and non-specific) reactivity is an atypical perinuclear antineutrophil cytoplasmic antibody (p-ANCA), also termed perinuclear anti-neutrophil nuclear antibodies (p-ANNA) and second the childhood disease called autoimmune sclerosing cholangitis (ASC) with serological features resembling those of type 1 AIH.
Liver diagnostic serology is a fast-expanding area of investigation as new purified and recombinant autoantigens, and automated technologies such as ELISAs and bead assays, become available to complement (or even compete with) traditional immunofluorescence procedures.
We survey for the first time global trends in quality assurance impacting as it does on (1) manufacturers/purveyors of kits and reagents, (2) diagnostic service laboratories that fulfill clinicians’ requirements, and (3) the end-user, the physician providing patient care, who must properly interpret test results in the overall clinical context.
The timecourse of induction of brain-derived neurotrophic factor mRNA and protein in the rat hippocampus following voluntary exercise.
In this study we examined the timecourse of induction of brain-derived neurotrophic factor (BDNF) mRNA and protein after 1, 3, 5, 7, 14 and 28 days of exercise in the rat. To measure the expression of mRNA for individual BDNF exons we utilized a semi-quantitative RT-PCR technique, while BDNF protein was assessed using
commercial ELISA kits. We demonstrated that the distance run by animals increased significantly (P<0.05) after 4 weeks.
BDNF protein was significantly (P<0.05) increased after 4 weeks of exercise, while the mRNA for individual BDNF exons increased significantly (P<0.05) over the timecourse (exon I after 1 and 28 days and exons II and V after 28 days).
The Morris water maze was then utilized to demonstrate that 3 weeks of prior exercise enhanced the rate of learning on this task. Exercise, therefore, was shown to modulate BDNF induction in a time-dependent manner, and this may translate to improvements in neurotrophin-mediated tasks within the CNS.

Dog Embryonic Ectoderm Development ELISA kit

E08E0041-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Canine Embryonic Ectoderm Development in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Embryonic Ectoderm Development ELISA kit

E08E0041-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Canine Embryonic Ectoderm Development in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Embryonic Ectoderm Development ELISA kit

E08E0041-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Canine Embryonic Ectoderm Development in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Embryonic Ectoderm Development ELISA kit

E07E0041-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Porcine Embryonic Ectoderm Development in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Embryonic Ectoderm Development ELISA kit

E07E0041-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Porcine Embryonic Ectoderm Development in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Embryonic Ectoderm Development ELISA kit

E07E0041-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Porcine Embryonic Ectoderm Development in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse S100A8/S100A9 Heterodimer ELISA development kit

DEIABL64 96T
EUR 889.2
Description: For the development of sandwich ELISAs to measure natural and recombinant mouse S100 Calcium Binding Protein A8 and S100 Calcium Binding Protein A9 Heterodimer (S100A8/S100A9 Heterodimer). The Reagent Diluent recommended may be suitable for most cell culture supernate, serum, and plasma samples. The Reagent Diluent selected for use can alter the performance of an immunoassay. Reagent Diluent optimization for samples with complex matrices such as serum and plasma, may improve their performance in this assay. This kit contains sufficient materials to run ELISAs on at least five 96 well plates, provided the following conditions are met: • The reagents are prepared as described in this package insert. • The assay is run as described in the General ELISA Protocol. • The recommended microplates, buffers, diluents, substrates, and solutions are used. This package insert must be read in its entirety before using this product. Refer to the Certificate of Analysis for component concentrations as they may vary. For research use only. Not for use in diagnostic procedures.

Human S100A8/S100A9 Heterodimer ELISA development kit

DEIABL65 96T
EUR 889.2
Description: For the development of sandwich ELISAs to measure natural and recombinant human S100 Calcium Binding Protein A8/S100 Calcium Binding Protein A9 (S100A8/S100A9 Heterodimer). The Reagent Diluent recommended may be suitable for most cell culture supernate, serum, plasma, saliva, human milk, urine, and fecal samples. The Reagent Diluent selected for use can alter the performance of an immunoassay. Reagent Diluent optimization for samples with complex matrices such as serum, plasma, saliva, human milk, urine, and feces, may improve their performance in this assay. This kit contains sufficient materials to run ELISAs on at least five 96 well plates, provided the following conditions are met: • The reagents are prepared as described in this package insert. • The assay is run as described in the General ELISA Protocol. • The recommended microplates, buffers, diluents, substrates, and solutions are used. *This package insert must be read in its entirety before using this product. Refer to the Certificate of Analysis for component concentrations as they may vary. For research use only. Not for use in diagnostic procedures.

Goat Embryonic Ectoderm Development ELISA kit

E06E0041-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Goat Embryonic Ectoderm Development in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Embryonic Ectoderm Development ELISA kit

E06E0041-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Goat Embryonic Ectoderm Development in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Embryonic Ectoderm Development ELISA kit

E06E0041-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Goat Embryonic Ectoderm Development in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Embryonic Ectoderm Development ELISA kit

E03E0041-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Mouse Embryonic Ectoderm Development in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Embryonic Ectoderm Development ELISA kit

E03E0041-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Mouse Embryonic Ectoderm Development in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Embryonic Ectoderm Development ELISA kit

E03E0041-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Mouse Embryonic Ectoderm Development in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Embryonic Ectoderm Development ELISA kit

E01E0041-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Human Embryonic Ectoderm Development in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Embryonic Ectoderm Development ELISA kit

E01E0041-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Human Embryonic Ectoderm Development in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Embryonic Ectoderm Development ELISA kit

E01E0041-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Human Embryonic Ectoderm Development in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Embryonic Ectoderm Development ELISA kit

E04E0041-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rabbit Embryonic Ectoderm Development in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Embryonic Ectoderm Development ELISA kit

E04E0041-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rabbit Embryonic Ectoderm Development in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Embryonic Ectoderm Development ELISA kit

E04E0041-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rabbit Embryonic Ectoderm Development in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Embryonic Ectoderm Development ELISA kit

E09E0041-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Monkey Embryonic Ectoderm Development in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Embryonic Ectoderm Development ELISA kit

E09E0041-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Monkey Embryonic Ectoderm Development in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Embryonic Ectoderm Development ELISA kit

E09E0041-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Monkey Embryonic Ectoderm Development in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Embryonic Ectoderm Development (EED) ELISA Kit

abx360493-96tests 96 tests
EUR 990

Rat Embryonic Ectoderm Development (EED) ELISA Kit

abx353662-96tests 96 tests
EUR 943.2

Human Embryonic Ectoderm Development (EED) ELISA Kit

abx351888-96tests 96 tests
EUR 801.6

Mouse Embryonic Ectoderm Development (EED) ELISA Kit

abx352684-96tests 96 tests
EUR 943.2

Rabbit Embryonic Ectoderm Development (EED) ELISA Kit

abx363232-96tests 96 tests
EUR 990

Monkey Embryonic Ectoderm Development (EED) ELISA Kit

abx358925-96tests 96 tests
EUR 990

Guinea pig Embryonic Ectoderm Development ELISA kit

E05E0041-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Guinea pig Embryonic Ectoderm Development in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Embryonic Ectoderm Development ELISA kit

E05E0041-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Guinea pig Embryonic Ectoderm Development in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Embryonic Ectoderm Development ELISA kit

E05E0041-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Guinea pig Embryonic Ectoderm Development in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Chicken Embryonic Ectoderm Development (EED) ELISA Kit

abx356729-96tests 96 tests
EUR 990

ELISA kit for Rat EED (Embryonic Ectoderm Development)

E-EL-R0360 1 plate of 96 wells
EUR 640.8
Description: A sandwich ELISA kit for quantitative measurement of Rat EED (Embryonic Ectoderm Development) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Mouse EED (Embryonic Ectoderm Development)

E-EL-M0449 1 plate of 96 wells
EUR 640.8
Description: A sandwich ELISA kit for quantitative measurement of Mouse EED (Embryonic Ectoderm Development) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Human EED (Embryonic Ectoderm Development)

E-EL-H1800 1 plate of 96 wells
EUR 640.8
Description: A sandwich ELISA kit for quantitative measurement of Human EED (Embryonic Ectoderm Development) in samples from Serum, Plasma, Cell supernatant

Rat Craniofacial Development Protein 1 (CFDP1) ELISA Kit

abx391152-96tests 96 tests
EUR 1093.2

Rat Craniofacial development protein 1(CFDP1) ELISA kit

E02C1631-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Rat Craniofacial development protein 1(CFDP1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Craniofacial development protein 1(CFDP1) ELISA kit

E02C1631-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Rat Craniofacial development protein 1(CFDP1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Craniofacial development protein 1(CFDP1) ELISA kit

E02C1631-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Rat Craniofacial development protein 1(CFDP1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Craniofacial development protein 1(CFDP1) ELISA kit

E08C1631-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Canine Craniofacial development protein 1(CFDP1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Craniofacial development protein 1(CFDP1) ELISA kit

E08C1631-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Canine Craniofacial development protein 1(CFDP1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Craniofacial development protein 1(CFDP1) ELISA kit

E08C1631-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Canine Craniofacial development protein 1(CFDP1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Craniofacial development protein 1(CFDP1) ELISA kit

E07C1631-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Porcine Craniofacial development protein 1(CFDP1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Craniofacial development protein 1(CFDP1) ELISA kit

E07C1631-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Porcine Craniofacial development protein 1(CFDP1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Craniofacial development protein 1(CFDP1) ELISA kit

E07C1631-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Porcine Craniofacial development protein 1(CFDP1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Craniofacial development protein 1(CFDP1) ELISA kit

E06C1631-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Goat Craniofacial development protein 1(CFDP1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Craniofacial development protein 1(CFDP1) ELISA kit

E06C1631-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Goat Craniofacial development protein 1(CFDP1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Craniofacial development protein 1(CFDP1) ELISA kit

E06C1631-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Goat Craniofacial development protein 1(CFDP1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Mesoderm development candidate 1, Mesdc1 ELISA KIT

ELI-36441m 96 Tests
EUR 1038

Human Mesoderm development candidate 1, MESDC1 ELISA KIT

ELI-16323h 96 Tests
EUR 988.8

Mouse Craniofacial Development Protein 1 (CFDP1) ELISA Kit

abx388924-96tests 96 tests
EUR 1093.2

Human Craniofacial Development Protein 1 (CFDP1) ELISA Kit

abx384736-96tests 96 tests
EUR 1093.2

Human Craniofacial development protein 1(CFDP1) ELISA kit

E01C1631-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Human Craniofacial development protein 1(CFDP1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Craniofacial development protein 1(CFDP1) ELISA kit

E01C1631-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Human Craniofacial development protein 1(CFDP1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Craniofacial development protein 1(CFDP1) ELISA kit

E01C1631-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Human Craniofacial development protein 1(CFDP1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Craniofacial development protein 1(CFDP1) ELISA kit

E03C1631-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Mouse Craniofacial development protein 1(CFDP1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Craniofacial development protein 1(CFDP1) ELISA kit

E03C1631-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Mouse Craniofacial development protein 1(CFDP1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Craniofacial development protein 1(CFDP1) ELISA kit

E03C1631-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Mouse Craniofacial development protein 1(CFDP1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Craniofacial development protein 1, CFDP1 ELISA KIT

ELI-34159h 96 Tests
EUR 988.8

Mouse Craniofacial development protein 1, Cfdp1 ELISA KIT

ELI-10533m 96 Tests
EUR 1038

Cfdp1 ELISA Kit| Mouse Craniofacial development protein 1 ELISA

EF014551 96 Tests
EUR 826.8

Rabbit Craniofacial development protein 1(CFDP1) ELISA kit

E04C1631-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Rabbit Craniofacial development protein 1(CFDP1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Craniofacial development protein 1(CFDP1) ELISA kit

E04C1631-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Rabbit Craniofacial development protein 1(CFDP1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Craniofacial development protein 1(CFDP1) ELISA kit

E04C1631-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Rabbit Craniofacial development protein 1(CFDP1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Craniofacial development protein 1(CFDP1) ELISA kit

E09C1631-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Monkey Craniofacial development protein 1(CFDP1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Craniofacial development protein 1(CFDP1) ELISA kit

E09C1631-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Monkey Craniofacial development protein 1(CFDP1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.